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金雀异黄酮 95%
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- 品 牌：
- 江蓝纯(Gelatins)
- 产品名：金雀异黄酮 95%
CAS号：446-72-0
分子式：C15H10O5
分子量：270.24
Beilstein号：263823
EC号： 207-174-9
MDL号： MFCD00016952
PubChem编号：24278036
属性
敏感性 否
存贮条件 储存温度 -20°C
熔点 297-298°C
密度 1.5480
荧光 否
IC50 否
pK Values 否
描述
别名 金雀异黄酮 ;4‘,5,7-三羟基异黄酮,染料木黄酮, 染料木素;4‘,5,7-Trihydroxyisoflavone 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
产品介绍 溶于乙醇和DMSO， 干冷处保存。
用途 1、具有雌性激素及抗雌激素性质 2、在体内能抑制结肠癌、乳腺癌、皮肤癌、前列腺癌等 3、对多种肿瘤细胞株有抑制作用 4、具有抗氧化作用 5、可以抑制酪氨酸蛋白激酶（PTK）的活性 6、可以抑制拓扑异购酶Ⅱ的活性 7、可以预防绝经后骨质疏松 8、具有诱发细胞程序性死亡、提高抗癌药效、抑制血管生成等作用，是一种很有潜力的癌症化学预防剂，其抗癌作用及机制具有广泛的应用前景。
生化机理
Description:
IC50 Value: 37.5 uM( Topo II) [3]
Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. It has been shown that genistein inhibits many type of cancers including prostate cancer (PCa) by regulating several cell signaling pathways and microRNAs (miRNAs).
in vitro: GEN effectively reversed estrogenicity of BPA by reversing mRNA and protein expressions of ERα, IGF-1R, pIRS-1, and pAkt induced by BPA in cellular model and also significantly decreased tumor growth and in vivo expressions of ERα, pIRS-1, and pAkt in xenografted mouse model [1]. Interestingly, genistein and its analogs induced caspase 3-activation supporting apoptotic mechanism of cell death but SPG-G supported caspase 3-independent apoptosis [2]. Of the compounds tested, only genistein selectively inhibited human topo II activity and had an IC50 value of 37.5 ?M [3]
in vivo: Genistein significantly decreased the blood levels of total cholesterol, triglycerides, homocysteine and visfatin compared with placebo, while blood adiponectin levels were increased [4]. Leucine and genistein significantly (p<0.05) reduced the number of fights and increased latency to fights in foot shock-induced aggression; it also decreased apomorphine (5mg/kg, i.p.) induced stereotyped behavior and apomorphine induced (10mg/kg, s.c.) locomotor activity when compared with the positive control group [5].
Clinical trial: Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer. Phase 2
江西江蓝纯生物试剂有限公司
- 地址：
- 江西省抚州市抚州高新技术产业开发区金柅大道198号科创孵化基地中小创业企业园B2栋二楼
