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- 关键字:RESOMER 生物可降解聚合物
RESOMER 是赢创旗下一系列生物可降解聚合物的商品名。这类聚合物由丙交酯和乙交酯聚合而成。通过调整分子量,单体比例或加入其它单体,在植入或注射后在人体组织内按照一定速率降解。体液能将聚合物水解为低聚体甚至为羟基酸单体,最终为人体代谢。RESOMER®在多种应用中均表现出了良好的生物相容性:例如:整形外科固定件,提供粉末形态供药物制剂使用。RESOMER稳定性考察表明聚合物在合适的条件下能长期存放。
具体产品如下:
名称 分子量 粘性 用途 Tg [℃] Tm [℃] 末端基
RESOMER L 206 S
Poly(L-lactide) -- 0.8 - 1.2 Medical Device 60 - 65 180 - 185 alkyl ester
RESOMER R 202 S
Poly(D,L-lactide) 10,000 -
18,000 0.16 - 0.24 Controlled Release 38 - 42 amorphous alkyl ester
RESOMER R 202 H
Poly(D,L-lactide) 10,000 -
18,000 0.16 - 0.24 Controlled Release 44 - 48 amorphous free carboxylic acid
RESOMER R 203 S
Poly(D,L-lactide) 18,000 -
28,000 0.25 - 0.35 Controlled Release 46 - 50 amorphous Alkyl ester
RESOMER R 203 H
Poly(D,L-lactide) 18,000 -
28,000 0.25 - 0.35 Controlled Release 48 - 52 amorphous free carboxylic acid
RESOMER RG 502
Poly(D,L-lactide-co-glycolide) 50:50 7,000 -
17,000 0.16 - 0.24 Controlled Release 42 - 46 amorphous alkyl ester
RESOMER RG 502 H
Poly(D,L-lactide-co-glycolide) 50:50 7,000 -
17,000 0.16 - 0.24 Controlled Release 42 - 46 amorphous free carboxylic acid
RESOMER RG503
Poly(D,L-lactide-co-glycolide) 50:50 24,000 -
38,000 0.32 - 0.44 Controlled Release - amorphous alkyl ester
RESOMER RG 503 H
Poly(D,L-lactide-co-glycolide) 50:50 24,000 -
38,000 0.32 - 0.44 Controlled Release 44 - 48 amorphous free carboxylic acid
RESOMER RG504
Poly(D,L-lactide-co-glycolide) 50:50 38,000 -
54,000 0.45 - 0.60 Controlled Release - amorphous alkyl ester
RESOMER RG 504 H
Poly(D,L-lactide-co-glycolide) 50:50 38,000 -
54,000 0.45 - 0.60 Controlled Release 46 - 50 amorphous free carboxylic acid
RESOMER RG505
Poly(D,L-lactide-co-glycolide) 50:50 54,000 -
69,000 0.61 - 0.74 Controlled Release - amorphous alkyl ester
RESOMER RG 653 H
Poly(D,L-lactide-co-glycolide) 65:35 24,000 -
38,000 0.32 - 0.44 Controlled Release 46 - 50 amorphous free carboxylic acid
RESOMER RG 752 H
Poly(D,L-lactide-co-glycolide) 75:25 4,000 -
15,000 0.14 - 0.22 Controlled Release 42 - 46 amorphous free carboxylic acid
RESOMER RG 756 S
Poly(D,L-lactide-co-glycolide) 75:25 76,000 -
116,000 0.71 - 1.0 Controlled Release 49 - 55 amorphous alkyl ester
RESOMER RG858 S
Poly(D,L-lactide-co-glycolide) 85:15 190,000 -
240,000 1.3 - 1.7 Controlled Release - amorphous alkyl ester
RESOMER X
Polydioxanone -- 1.5 - 2.2
(0.1% in HFIP, 30℃) Medical Device -10 -
-5 110 - 115 --